Synonyms to pain in the neck

aggravation, annoyance, bad news, bedevilment, bore, bother, botheration, bothersomeness, buttonholer, crashing bore, devilment, difficulty, dogging, downer, drag, drip, dryasdust, dusty, exasperation, flat tire, frightful bore, harassment, harrying, headache, hounding, humdrum, molestation, nuisance, persecution, pest, pill, problem, proser, trial, trouble, twaddler, vexation, vexatiousness, wet blanket, worriment, worry